Pub. Date : 2013 May 3
PMID : 23508953
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |
| 2 | The scaffold protein ISCU facilitates the assembly of iron-sulfur clusters (ISCs), which are essential cofactors for many vital metabolic processes. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |
| 3 | Sustained ISCU protein levels enhanced by mTORC1 sensitized TSC2-null cells to iron deprivation due to constitutive ISC biogenesis-triggered iron demand, which outstrips supply. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |
| 4 | Sustained ISCU protein levels enhanced by mTORC1 sensitized TSC2-null cells to iron deprivation due to constitutive ISC biogenesis-triggered iron demand, which outstrips supply. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |