Title : Sex dependent influence of a functional polymorphism in steroid 5-α-reductase type 2 (SRD5A2) on post-traumatic stress symptoms.

Pub. Date : 2013 Apr

PMID : 23505265






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A non-synonymous, single nucleotide polymorphism (SNP) in the gene coding for steroid 5-alpha-reductase type 2 (SRD5A2) is associated with reduced conversion of testosterone to dihydrotestosterone (DHT). Testosterone steroid 5 alpha-reductase 2 Homo sapiens
2 A non-synonymous, single nucleotide polymorphism (SNP) in the gene coding for steroid 5-alpha-reductase type 2 (SRD5A2) is associated with reduced conversion of testosterone to dihydrotestosterone (DHT). Testosterone steroid 5 alpha-reductase 2 Homo sapiens
3 Because SRD5A2 participates in the regulation of testosterone and cortisol metabolism, hormones shown to be dysregulated in patients with PTSD, we examined whether the V89L variant (rs523349) influences risk for post-traumatic stress disorder (PTSD). Testosterone steroid 5 alpha-reductase 2 Homo sapiens