Title : Chronic estrogen deficiency causes gastroparesis by altering neuronal nitric oxide synthase function.

Pub. Date : 2013 Jun

PMID : 23504347






4 Functional Relationships(s)
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1 AIMS: The purpose of this study was to investigate whether reduced levels of estradiol-17beta (E2) down-regulates tetrahydrobiopterin (BH4, a cofactor for nNOS dimerization and enzyme activity) biosynthesis and therefore nNOS mediated gastric motility would be impaired in a mouse model of chronic estrogen deficiency, follicle stimulating hormone receptor knock-out female mice (FORKO). sapropterin nitric oxide synthase 1, neuronal Mus musculus
2 AIMS: The purpose of this study was to investigate whether reduced levels of estradiol-17beta (E2) down-regulates tetrahydrobiopterin (BH4, a cofactor for nNOS dimerization and enzyme activity) biosynthesis and therefore nNOS mediated gastric motility would be impaired in a mouse model of chronic estrogen deficiency, follicle stimulating hormone receptor knock-out female mice (FORKO). sapropterin nitric oxide synthase 1, neuronal Mus musculus
3 AIMS: The purpose of this study was to investigate whether reduced levels of estradiol-17beta (E2) down-regulates tetrahydrobiopterin (BH4, a cofactor for nNOS dimerization and enzyme activity) biosynthesis and therefore nNOS mediated gastric motility would be impaired in a mouse model of chronic estrogen deficiency, follicle stimulating hormone receptor knock-out female mice (FORKO). sapropterin nitric oxide synthase 1, neuronal Mus musculus
4 AIMS: The purpose of this study was to investigate whether reduced levels of estradiol-17beta (E2) down-regulates tetrahydrobiopterin (BH4, a cofactor for nNOS dimerization and enzyme activity) biosynthesis and therefore nNOS mediated gastric motility would be impaired in a mouse model of chronic estrogen deficiency, follicle stimulating hormone receptor knock-out female mice (FORKO). sapropterin nitric oxide synthase 1, neuronal Mus musculus