Title : Inhibition of histidine, decarboxylation in vivo by 2-hydroxy-5-carbomethoxybenzyloxyamine, a new, potent inhibitor of histidine decarboxylase.

Pub. Date : 1975 Feb

PMID : 235021






3 Functional Relationships(s)
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1 Inhibition of histidine, decarboxylation in vivo by 2-hydroxy-5-carbomethoxybenzyloxyamine, a new, potent inhibitor of histidine decarboxylase. 2-hydroxy-5-carbomethoxybenzyloxyamine histidine decarboxylase Rattus norvegicus
2 Intraperitoneal administration of 2-hydroxy-5-carbomethoxybenzyloxyamine, a new potent inhibitor of histidine decarboxylase, reduced the rate of 14CO2 production from C-His and R-His in a dose-dependent manner. 2-hydroxy-5-carbomethoxybenzyloxyamine histidine decarboxylase Rattus norvegicus
3 Rats given 2-hydroxy-5-carbomethoxybenzyloxyamine (100 mg/kg) by the intraperitoneal route had diminished histidine decarboxylase activity of stomach (96 percent decrease), but did not have any change in the activities of histidase, urocanase or histidine-pyruvate aminotransferase of liver. 2-hydroxy-5-carbomethoxybenzyloxyamine histidine decarboxylase Rattus norvegicus