Title : The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors.

Pub. Date : 2013 May 1

PMID : 23500543






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The loop exchange entailed significant effects: The A2A-selective agonist CGS21680, while being completely inactive at A2BARs, showed high affinity for the mutant A2B(EL2-A2A)AR, and was able to fully activate the receptor. 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine spectrin alpha, erythrocytic 1 Homo sapiens