Title : PDE3, but not PDE4, reduces β₁ - and β₂-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients.

Pub. Date : 2013 Jun

PMID : 23489141






1 Functional Relationships(s)
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1 The effects of (-)-noradrenaline, mediated through beta1 adrenoceptors (beta2 adrenoceptors blocked with ICI118551), and (-)-adrenaline, mediated through beta2 adrenoceptors (beta1 adrenoceptors blocked with CGP20712A), were assessed in the absence and presence of PDE inhibitors. Norepinephrine UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens