Title : Inhibition of telomerase activity by oleanane triterpenoid CDDO-Me in pancreatic cancer cells is ROS-dependent.

Pub. Date : 2013 Mar 13

PMID : 23486104






1 Functional Relationships(s)
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1 Furthermore, blocking ROS generation also prevented the inhibition of hTERT gene expression, hTERT protein production and expression of a number of hTERT-regulatory proteins by CDDO-Me (e.g., c-Myc, Sp1, NF-kappaB and p-Akt). bardoxolone methyl MYC proto-oncogene, bHLH transcription factor Homo sapiens