Title : Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice.

Pub. Date : 2013 Jul

PMID : 23478657






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Functionally diazepam appeared to counteract the endogenous down-regulation of GABAA signaling during infection. Diazepam gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus
2 Consistent with augmented GABAA signaling, diazepam provoked intracellular acidosis in macrophage, leading to impaired cytokine production, bacterial phagocytosis and killing. Diazepam gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus