Pub. Date : 2013 Apr
PMID : 23471219
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Also, MKP-2 down-regulation by MKP-2 shRNA increased the stimulatory effect of 8Br-cAMP on both promoter activity and messenger levels of CYP11A1, which encodes for the steroidogenic enzyme P450scc and is induced by LH/hCG through protein kinase A and ERK1/2 activities. | 8-Bromo Cyclic Adenosine Monophosphate | cytochrome P450, family 11, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Also, MKP-2 down-regulation by MKP-2 shRNA increased the stimulatory effect of 8Br-cAMP on both promoter activity and messenger levels of CYP11A1, which encodes for the steroidogenic enzyme P450scc and is induced by LH/hCG through protein kinase A and ERK1/2 activities. | 8-Bromo Cyclic Adenosine Monophosphate | cytochrome P450, family 11, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Our findings demonstrate, for the first time, that LH/hCG tightly regulates MKP-2 expression, which modulates the induction of CYP11A1 by 8Br-cAMP. | 8-Bromo Cyclic Adenosine Monophosphate | cytochrome P450, family 11, subfamily a, polypeptide 1 | Mus musculus |