Pub. Date : 2013 May
PMID : 23470622
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mTOR pathway involves two independent complexes, mTORC1 and mTORC2, which phosphorylate S6 kinase (S6K) and serine/threonine kinase (Akt), respectively, and differ in their sensitivity to rapamycin. | Sirolimus | ribosomal protein S6 kinase B1 | Rattus norvegicus |
| 2 | The mTOR pathway involves two independent complexes, mTORC1 and mTORC2, which phosphorylate S6 kinase (S6K) and serine/threonine kinase (Akt), respectively, and differ in their sensitivity to rapamycin. | Sirolimus | ribosomal protein S6 kinase B1 | Rattus norvegicus |
| 3 | Treatment with rapamycin (0.5 muM) or the Akt inhibitor, A-443654 (0.5 muM), reduced FCS-stimulated growth of PA-SMCs from MCT-PH rats to the level in control rats while inhibiting Akt, GSK3, and S6K activation. | Sirolimus | ribosomal protein S6 kinase B1 | Rattus norvegicus |