Title : PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.

Pub. Date : 2013 Apr 1

PMID : 23466229






1 Functional Relationships(s)
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1 The modification of the inhibitor scaffold of 1 and 2 from a dihydroquinolinone core to a tetrahydropyrazolopyridinone core led to discovery of a new series of potent KAT II inhibitors with excellent physicochemical properties. tetrahydropyrazolopyridinone thiosulfate sulfurtransferase like domain containing 1 Homo sapiens