Pub. Date : 2013
PMID : 23457308
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramide mediates inhibition of the Akt/eNOS pathway by high levels of glucose in human vascular endothelial cells. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | OBJECTIVE: To investigate how ceramide mediates the effects of high-glucose-induced inhibition of the Akt/endothelial nitric oxide synthase (eNOS) signalling pathway in human vascular endothelial cells (HUVECs). | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Preventing de novo ceramide synthesis attenuated the antagonistic effects of high-glucose levels on the Akt/eNOS signalling pathway (p<0.05); conversely, inducing ceramide build-up augmented the inhibitory effects of high-glucose levels on the Akt/eNOS signalling pathway (p<0.05). | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Preventing de novo ceramide synthesis attenuated the antagonistic effects of high-glucose levels on the Akt/eNOS signalling pathway (p<0.05); conversely, inducing ceramide build-up augmented the inhibitory effects of high-glucose levels on the Akt/eNOS signalling pathway (p<0.05). | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | CONCLUSION: Ceramide is both necessary and sufficient for mediating the inhibition of the Akt/eNOS signalling pathway by high-glucose levels in endothelial cells. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |