Title : Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma.

Pub. Date : 2013 May

PMID : 23449276






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Increased activity of pemetrexed occurs by folylpolyglutamate synthetase (FPGS), intracellular transport by reduced folate carrier (RFC). Folic Acid solute carrier family 19 member 1 Homo sapiens
2 Folate uptake mechanisms by RFC and activation by FPGS were associated with clinical benefit from pemetrexed treatment. Folic Acid solute carrier family 19 member 1 Homo sapiens