Pub. Date : 2013 Apr
PMID : 23443505
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine favors osteoclastogenesis in human periodontal ligament cells co-cultured with CD4(+) T cells by upregulating IL-1beta. | Nicotine | interleukin 1 beta | Homo sapiens |
| 2 | Compared with mono-culture systems, stimulation with nicotine caused an increased secretion of IL-1beta in serum of human PDL cell-CD4(+) T cell co-culture, and the expression of RANKL in human PDL cells was further upregulated co-cultured with CD4(+) T cells, while no differences were observed in the expression of OPG between the co-culture and mono-culture systems. | Nicotine | interleukin 1 beta | Homo sapiens |
| 3 | Our data suggested that nicotine upregulated IL-1beta secretion, further upregulated RANKL expression in smoking-associated periodontitis, which may aid in the better understanding of the relationship between nicotine and alveolar bone resorption. | Nicotine | interleukin 1 beta | Homo sapiens |
| 4 | Our data suggested that nicotine upregulated IL-1beta secretion, further upregulated RANKL expression in smoking-associated periodontitis, which may aid in the better understanding of the relationship between nicotine and alveolar bone resorption. | Nicotine | interleukin 1 beta | Homo sapiens |