Title : Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid.

Pub. Date : 2013 Jul

PMID : 23434766






1 Functional Relationships(s)
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1 Furthermore, DMA increased hepatic glyoxalase mRNA and glutathione mediated by Nrf2 activation to metabolize MG into d-lactic acid, thereby reducing serum and hepatic AGE levels and suppressing inflammatory factor generation in MG-treated mice. Pyruvaldehyde nuclear factor, erythroid derived 2, like 2 Mus musculus