Title : Microcystin-LR induces endoplasmatic reticulum stress and leads to induction of NFκB, interferon-alpha, and tumor necrosis factor-alpha.

Pub. Date : 2013 Apr 2

PMID : 23431999






2 Functional Relationships(s)
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1 We focus on the endoplasmatic reticulum (ER) stress response or unfolded protein response (UPR), and on mechanisms that may contribute to the tumor-promoting effect of MCs in animals, including the activation of NFkappaB, the expression of interferon alpha (IFN-alpha) and the induction of interferon stimulated genes (ISGs), as well as the expression of tumor necrosis factor alpha (TNF-alpha). Microcystins tumor necrosis factor Homo sapiens
2 We focus on the endoplasmatic reticulum (ER) stress response or unfolded protein response (UPR), and on mechanisms that may contribute to the tumor-promoting effect of MCs in animals, including the activation of NFkappaB, the expression of interferon alpha (IFN-alpha) and the induction of interferon stimulated genes (ISGs), as well as the expression of tumor necrosis factor alpha (TNF-alpha). Microcystins tumor necrosis factor Homo sapiens