Title : Impairment of TrkB-PSD-95 signaling in Angelman syndrome.

Pub. Date : 2013

PMID : 23424281






1 Functional Relationships(s)
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Protein Name
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1 A bridged cyclic peptide (CN2097), shown by nuclear magnetic resonance (NMR) studies to uniquely bind the PDZ1 domain of PSD-95 with high affinity, decreased the interaction of Arc with PSD-95 to restore BDNF-induced TrkB/PSD-95 complex formation, signaling, and facilitate the induction of LTP in AS mice. Peptides, Cyclic brain derived neurotrophic factor Mus musculus