Title : Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.

Pub. Date : 2013

PMID : 23420416






1 Functional Relationships(s)
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1 The linkage between protein motions and catalysis is investigated in the context of a model enzyme, E. coli dihydrofolate reductase (DHFR), that catalyzes the hydride transfer reaction in the conversion of dihydrofolate to tetrahydrofolate. dihydrofolate Dihydrofolate reductase Escherichia coli