Pub. Date : 2013 Jun
PMID : 23416210
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bortezomib sensitivity of acute myeloid leukemia CD34(+) cells can be enhanced by targeting the persisting activity of NF-kappaB and the accumulation of MCL-1. | Bortezomib | CD34 molecule | Homo sapiens |
| 2 | In this study, we questioned whether leukemic stem cell-enriched CD34(+) cells are sensitive to the proteasome inhibitor bortezomib. | Bortezomib | CD34 molecule | Homo sapiens |
| 3 | Surprisingly, we observed in short-term and long-term culture assays that CD34(-) AML cells were more sensitive to bortezomib treatment compared with the CD34(+) AML cells at a clinical relevant dosage. | Bortezomib | CD34 molecule | Homo sapiens |
| 4 | The better survival of CD34(+) AML cells upon bortezomib treatment was due to a persisting NF-kappaB activity that could be overcome by the IKK inhibitor BMS-345541. | Bortezomib | CD34 molecule | Homo sapiens |
| 5 | MCL-1 accumulated in CD34(+) AML cells upon bortezomib treatment and inhibition of MCL-1 by shRNA, or Obatoclax, significantly improved the sensitivity of CD34(+) AML cells to bortezomib. | Bortezomib | CD34 molecule | Homo sapiens |