Pub. Date : 2013 Feb 7
PMID : 23392173
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silencing of SHP-1 by small interference RNA (siRNA) reduced the effect of sorafenib on P-STAT3 and autophagy. | Sorafenib | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |
| 2 | Furthermore, our in vivo data showed that both sorafenib and SC-59 inhibited tumor growth, downregulated P-STAT3, enhanced the activity of SHP-1 and induced autophagy in PLC5 tumors, suggesting that sorafenib and SC-59 activate autophagy in HCC. | Sorafenib | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |
| 3 | Furthermore, our in vivo data showed that both sorafenib and SC-59 inhibited tumor growth, downregulated P-STAT3, enhanced the activity of SHP-1 and induced autophagy in PLC5 tumors, suggesting that sorafenib and SC-59 activate autophagy in HCC. | Sorafenib | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |
| 4 | In conclusion, sorafenib and SC-59 induce autophagy in HCC through a SHP-1-STAT3-Mcl-1-Beclin 1 pathway. | Sorafenib | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |