Title : Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome.

Pub. Date : 2013

PMID : 23383345






2 Functional Relationships(s)
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1 Our data indicate that bortezomib activated autophagy in a dose- and time- dependent manner in HCC cell lines including Huh-7, Sk-Hep1, and Hep3B. Bortezomib MIR7-3 host gene Homo sapiens
2 Moreover, our in vivo data showed that both bortezomib and DeltaBtz inhibited tumor growth, downregulated CIP2A, P-Akt and induced autophagy in Huh-7 tumors. Bortezomib MIR7-3 host gene Homo sapiens