Pub. Date : 2013
PMID : 23383146
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeted delivery of immunotoxin by antibody to ganglioside GD3: a novel drug delivery route for tumor cells. | Gangliosides | GRDX | Homo sapiens |
| 2 | The expression of ganglioside GD3, which plays essential roles in normal brain development, decreases in adults but is up regulated in neuroectodermal and epithelial derived cancers. | Gangliosides | GRDX | Homo sapiens |
| 3 | R24 antibody, directed against ganglioside GD3, is a validated tumor target which is specifically endocytosed and accumulated in endosomes. | Gangliosides | GRDX | Homo sapiens |
| 4 | Thus, the ganglioside GD3 emerge as a novel and attractive class of cell surface molecule for targeted delivery of cytotoxic agents and, therefore, provides a rationale for future therapeutic intervention in cancer. | Gangliosides | GRDX | Homo sapiens |