Title : Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer.

Pub. Date : 2013 Feb 4

PMID : 23379261






1 Functional Relationships(s)
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1 RESULTS: We found that GE can reactivate ERalpha expression and this effect was synergistically enhanced when combined with a histone deacetylase (HDAC) inhibitor, trichostatin A (TSA), in ERalpha-negative MDA-MB-231 breast cancer cells. trichostatin A estrogen receptor 1 Homo sapiens