Title : The HER2- and heregulin β1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression.

Pub. Date : 2013 Apr

PMID : 23378579






1 Functional Relationships(s)
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1 Both the HER2- and HRG1-beta1-induced increase in Fn14 expression in MCF7 cells as well as basal Fn14 expression in HER2 gene-amplified AU565 cells could be reduced by HER2 kinase inhibition with lapatinib or combined HER2 and HER3 depletion using siRNA. Lapatinib erb-b2 receptor tyrosine kinase 3 Homo sapiens