Title : Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons.

Pub. Date : 2013 May

PMID : 23376588






1 Functional Relationships(s)
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1 These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production. Iron aconitase 1 Mus musculus