Title : Oxidative stress in malignant melanoma enhances tumor necrosis factor-α secretion of tumor-associated macrophages that promote cancer cell invasion.

Pub. Date : 2013 Oct 20

PMID : 23373752






1 Functional Relationships(s)
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1 We also revealed a role for high-level intracellular ROS in enhancing proinvasion signature of TAMs by strongly increasing their tumor necrosis factor alpha secretion, which is possibly attributed to ROS-enhanced peroxisome proliferator-activated receptor gamma (PPARgamma) translocation mediated by MAPK/ERK kinase 1. tams tumor necrosis factor Homo sapiens