Title : Genetic variants of the APE1 gene and the risk of vitiligo in a Chinese population: a genotype-phenotype correlation study.

Pub. Date : 2013 May

PMID : 23369758






2 Functional Relationships(s)
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1 Furthermore, serum 8-OHdG levels were elevated in the APE1-148Glu allele carriers (Asp/Glu+Glu/Glu), in an allele dose-response manner, with the risk of vitiligo (Ptrend<0.05). 8-ohdg apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens
2 In addition, we found that the APE1-148Glu variant increased the 8-OHdG levels of cultured human melanocytes treated with H2O2, without any impact on the endonuclease activity. 8-ohdg apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens