Title : Pharmacokinetic profile and safety of 150 mg of maraviroc dosed with 800/100 mg of darunavir/ritonavir all once daily, with and without nucleoside analogues, in HIV-infected subjects.

Pub. Date : 2013 Jun

PMID : 23364475






1 Functional Relationships(s)
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1 Although not statistically significant, a trend was observed towards lower maraviroc, darunavir and ritonavir concentrations in period 2 versus period 1; total maraviroc exposure was 3579 ng h/mL (95% CI: 2983-4294) and 2996 ng h/mL (95% CI: 2374-3782) in periods 1 and 2, respectively, and the GM ratio was 0.84 (95% CI: 0.67-1.05). Ritonavir period circadian regulator 2 Homo sapiens