Pub. Date : 2013 Mar
PMID : 23360948
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Switching p53 states by calcium: dynamics and interaction of stress systems. | Calcium | tumor protein p53 | Homo sapiens |
| 2 | The high dose of calcium in the system activates the nitric oxide synthase, synthesizing nitric oxide which then downregulates Mdm2 and influences drastically the p53-Mdm2 network regulation, lifting the system from a normal to a stressed state. | Calcium | tumor protein p53 | Homo sapiens |
| 3 | The increase in calcium level switches the system to different states, as identified by the different behaviours of the p53 temporal dynamics, i.e. oscillation death to sustain the oscillation state via a mixed state of dampened and oscillation death states. | Calcium | tumor protein p53 | Homo sapiens |