Title : Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants.

Pub. Date : 2013 Mar 15

PMID : 23351704






1 Functional Relationships(s)
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1 Here we describe linked intronic variants of MGAT5 that are associated with reduced N-glycan branching, CTLA-4 surface expression and MS (p=5.79x10(-9), n=7,741), the latter additive with the MGAT1, IL2RA and IL7RA MS risk variants (p=1.76x10(-9), OR=0.67-1.83, n=3,518). n-glycan mannoside acetylglucosaminyltransferase 5 Mus musculus