Pub. Date : 2013 Jun
PMID : 23349487
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The EP3 receptor is stimulated by prostaglandin E2 (PGE2) and couples to G-proteins of the Gi subfamily to decrease intracellular cAMP, blunting glucose-stimulated insulin secretion (GSIS). | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 2 | The EP3 receptor is stimulated by prostaglandin E2 (PGE2) and couples to G-proteins of the Gi subfamily to decrease intracellular cAMP, blunting glucose-stimulated insulin secretion (GSIS). | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 3 | We confirmed that the PGE2-to-EP3 signaling pathway was active in islets from confirmed diabetic BTBR mice and human cadaveric donors, with increased EP3 expression, PGE2 production, and function of EP3 agonists and antagonists to modulate cAMP production and GSIS. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 4 | We confirmed that the PGE2-to-EP3 signaling pathway was active in islets from confirmed diabetic BTBR mice and human cadaveric donors, with increased EP3 expression, PGE2 production, and function of EP3 agonists and antagonists to modulate cAMP production and GSIS. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |