Pub. Date : 2013 Mar
PMID : 23344581
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | BACKGROUND: Bupropion, an antidepressant and smoking cessation medication, is metabolized to hydroxybupropion (HB), an active metabolite, primarily by CYP2B6. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | OBJECTIVES: To compare plasma concentrations of bupropion and metabolites at steady state in healthy volunteers with and without CYP2B6 genetic variants. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | CONCLUSION: As HB is active and its steady-state concentrations are more than 10 times higher than bupropion, CYP2B6 variants are likely to affect pharmacological activity. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |