Pub. Date : 2013 Apr
PMID : 23344472
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. | Uric Acid | uromodulin | Homo sapiens |
| 2 | Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. | Uric Acid | uromodulin | Homo sapiens |
| 3 | Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. | Uric Acid | uromodulin | Homo sapiens |
| 4 | Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. | Uric Acid | uromodulin | Homo sapiens |
| 5 | Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. | Uric Acid | uromodulin | Homo sapiens |
| 6 | UMOD promoter variants displayed reciprocal effects on urine uric acid excretion and plasma uric acid concentration, suggesting a primary effect on renal tubular handling of urate. | Uric Acid | uromodulin | Homo sapiens |
| 7 | UMOD promoter variants displayed reciprocal effects on urine uric acid excretion and plasma uric acid concentration, suggesting a primary effect on renal tubular handling of urate. | Uric Acid | uromodulin | Homo sapiens |
| 8 | UMOD promoter variants displayed reciprocal effects on urine uric acid excretion and plasma uric acid concentration, suggesting a primary effect on renal tubular handling of urate. | Uric Acid | uromodulin | Homo sapiens |
| 9 | These UMOD genetic marker-on-trait associations for uric acid were replicated in the independent American cohort. | Uric Acid | uromodulin | Homo sapiens |
| 10 | Thus, UMOD promoter variants seem to initiate a cascade of transcriptional and biochemical changes influencing UMOD secretion, leading to altered plasma uric acid levels. | Uric Acid | uromodulin | Homo sapiens |
| 11 | Thus, UMOD promoter variants seem to initiate a cascade of transcriptional and biochemical changes influencing UMOD secretion, leading to altered plasma uric acid levels. | Uric Acid | uromodulin | Homo sapiens |