Title : Assessment of effects of IR and IPC on activities of cytochrome P450 isozymes in rats by a five-drug cocktail approach.

Pub. Date : 2014 Feb

PMID : 23339682






1 Functional Relationships(s)
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1 METHODS: Cocktail approach was used to evaluate the influence of IR and IPC on the activities of CYP1A2, CYP2C9, CYP2E1, CYP2D6 and CYP3A4, which were reflected by the changes of pharmacokinetic parameters of five specific probe drugs: caffeine, chlorzoxazone, tolbutamide, metoprolol and midazolam, respectively. Midazolam cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus