Pub. Date : 2013 Jan
PMID : 23339090
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of 14-3-3sigma in resistance to cisplatin in non-small cell lung cancer cells. | Cisplatin | stratifin | Homo sapiens |
| 2 | We have investigated whether the differential expression pattern of 14-3-3sigma affects cisplatin response in non-small cell lung cancer cell lines. | Cisplatin | stratifin | Homo sapiens |
| 3 | 14-3-3sigma mRNA expression increased in CR-A549 and CR-Calu1 compared with their cisplatin-sensitive parental A549 and Calu1 cell lines. | Cisplatin | stratifin | Homo sapiens |
| 4 | But when 14-3-3sigma expression was suppressed, elevated cisplatin response was seen in A549 and CR-Calu1 cell lines. | Cisplatin | stratifin | Homo sapiens |
| 5 | Increased 14-3-3sigma expression might also account for reduced cisplatin response in vivo, since, 14-3-3sigma expression in clinical biopsy samples obtained from lung cancer patients undergoing cisplatin-based chemotherapy significantly higher in the non-responder compared with the responder group. | Cisplatin | stratifin | Homo sapiens |
| 6 | Increased 14-3-3sigma expression might also account for reduced cisplatin response in vivo, since, 14-3-3sigma expression in clinical biopsy samples obtained from lung cancer patients undergoing cisplatin-based chemotherapy significantly higher in the non-responder compared with the responder group. | Cisplatin | stratifin | Homo sapiens |
| 7 | Increased 14-3-3sigma expression might also account for reduced cisplatin response in vivo, since, 14-3-3sigma expression in clinical biopsy samples obtained from lung cancer patients undergoing cisplatin-based chemotherapy significantly higher in the non-responder compared with the responder group. | Cisplatin | stratifin | Homo sapiens |
| 8 | We therefore propose that increased 14-3-3sigma expression is correlated with cisplatin response in non-small cell lung cancer cells; monitoring its expression might become useful in the future in predicting poor outcome to cisplatin treatment and/or the verification of acquired cisplatin resistance in lung cancer patients. | Cisplatin | stratifin | Homo sapiens |
| 9 | We therefore propose that increased 14-3-3sigma expression is correlated with cisplatin response in non-small cell lung cancer cells; monitoring its expression might become useful in the future in predicting poor outcome to cisplatin treatment and/or the verification of acquired cisplatin resistance in lung cancer patients. | Cisplatin | stratifin | Homo sapiens |
| 10 | We therefore propose that increased 14-3-3sigma expression is correlated with cisplatin response in non-small cell lung cancer cells; monitoring its expression might become useful in the future in predicting poor outcome to cisplatin treatment and/or the verification of acquired cisplatin resistance in lung cancer patients. | Cisplatin | stratifin | Homo sapiens |