Title : Functional analysis of a duplication (p.E63_D69dup) in the switch II region of HRAS: new aspects of the molecular pathogenesis underlying Costello syndrome.

Pub. Date : 2013 Apr 15

PMID : 23335589






1 Functional Relationships(s)
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1 Indeed, we identified strongly augmented active HRAS(E63_D69dup) that co-precipitated with effectors RAF1, RAL guanine nucleotide dissociation stimulator and phospholipase C1. Guanine Nucleotides RAS like proto-oncogene A Homo sapiens