Title : The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation.

Pub. Date : 2013 Mar 1

PMID : 23335512






3 Functional Relationships(s)
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1 The GPR40-dependent effect of GW9508 was confirmed using shRNA interference in osteoclast precursors and GPR40(-/-) primary cell cultures. GW9508 free fatty acid receptor 1 Mus musculus
2 The GPR40-dependent effect of GW9508 was confirmed using shRNA interference in osteoclast precursors and GPR40(-/-) primary cell cultures. GW9508 free fatty acid receptor 1 Mus musculus
3 In addition, in vivo administration of GW9508 counteracted ovariectomy-induced bone loss in wild-type but not GPR40(-/-) mice, enlightening the obligatory role of the GPR40 receptor. GW9508 free fatty acid receptor 1 Mus musculus