Title : Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells.

Pub. Date : 2013 Feb

PMID : 23333628






4 Functional Relationships(s)
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1 Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously. Histamine protein kinase C delta Homo sapiens
2 Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously. Histamine protein kinase C delta Homo sapiens
3 Quercetin also inhibited histamine- or PMA-induced phosphorylation of Tyr(311) of PKCdelta and translocation of PKCdelta to the Golgi. Histamine protein kinase C delta Homo sapiens
4 Quercetin also inhibited histamine- or PMA-induced phosphorylation of Tyr(311) of PKCdelta and translocation of PKCdelta to the Golgi. Histamine protein kinase C delta Homo sapiens