Title : Injectable hyaluronic acid-tyramine hydrogels incorporating interferon-α2a for liver cancer therapy.

Pub. Date : 2013 Mar 28

PMID : 23328125






5 Functional Relationships(s)
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1 IFN-alpha2a-incorporated HA-Tyr hydrogels of varying stiffness were formed by changing the H2O2 concentration. Tyrosine interferon alpha 2 Mus musculus
2 Through the caspase-3/7 pathway in vitro, IFN-alpha2a released from HA-Tyr hydrogels inhibited the proliferation of liver cancer cells and induced apoptosis. Tyrosine interferon alpha 2 Mus musculus
3 The tumor regression study revealed that IFN-alpha2a-incorporated HA-Tyr hydrogels effectively inhibited tumor growth, while the injection of an IFN-alpha2a solution did not demonstrate antitumor efficacy. Tyrosine interferon alpha 2 Mus musculus
4 Histological studies confirmed that tumor tissues in mice treated with IFN-alpha2a-incorporated HA-Tyr hydrogels showed lower cell density, with more apoptotic and less proliferating cells compared with tissues treated with an IFN-alpha2a solution. Tyrosine interferon alpha 2 Mus musculus
5 Histological studies confirmed that tumor tissues in mice treated with IFN-alpha2a-incorporated HA-Tyr hydrogels showed lower cell density, with more apoptotic and less proliferating cells compared with tissues treated with an IFN-alpha2a solution. Tyrosine interferon alpha 2 Mus musculus