Pub. Date : 2013 Apr
PMID : 23319419
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although ICA greatly attenuates ERG inactivation by shifting its voltage dependence to more positive potentials, it enhances the rate and extent of EAG inactivation without altering its voltage dependence. | isocyanic acid | ETS transcription factor ERG | Homo sapiens |
| 2 | Here, we investigate whether the inverse functional response to ICA in EAG and ERG channels is related to differences in ICA binding site or to intrinsic mechanisms of inactivation. | isocyanic acid | ETS transcription factor ERG | Homo sapiens |
| 3 | ICA is a mixed agonist of mutant EAG and EAG/ERG chimera channels that inactivate by a combination of slow and fast mechanisms. | isocyanic acid | ETS transcription factor ERG | Homo sapiens |
| 4 | With the exception of three residues, the specific amino acids that form the putative binding pocket for ICA in ERG are conserved in EAG. | isocyanic acid | ETS transcription factor ERG | Homo sapiens |
| 5 | Mutations introduced into EAG to replicate the ICA binding site in ERG did not alter the functional response to ICA. | isocyanic acid | ETS transcription factor ERG | Homo sapiens |
| 6 | Together these findings suggest that ICA binds to the same site in EAG and ERG channels to elicit opposite functional effects. | isocyanic acid | ETS transcription factor ERG | Homo sapiens |