Title : Design and characterization of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile Acid transporter activity.

Pub. Date : 2013 May

PMID : 23319170






2 Functional Relationships(s)
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1 METHODS: Target compound CA-lys-TFA was synthesized and tested for affinity toward the apical sodium dependent bile acid transporter (hASBT) and the Na+/taurocholate cotransporting polypeptide (hNTCP). ca-lys-tfa solute carrier family 10 member 1 Homo sapiens
2 RESULTS: CA-lys-TFA was a potent substrate of hASBT (Kt = 39.4 muM, normalized Vmax = 0.853) and hNTCP (Kt = 8.99 muM, normalized Vmax = 0.281). ca-lys-tfa solute carrier family 10 member 1 Homo sapiens