Title : The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression.

Pub. Date : 2013 Mar

PMID : 23314174






1 Functional Relationships(s)
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1 Notably, the combination of sorafenib and radiation eliminated CD44+CD24-/low cells preferentially, which highly expressed hypoxia-inducible factor (HIF)-1alpha and effectively inhibited primary and secondary mammosphere formation in MDA-MB-231 cells. Sorafenib CD44 molecule (Indian blood group) Homo sapiens