Pub. Date : 2013 Mar 15
PMID : 23306543
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin. | Bleomycin | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 2 | OBJECTIVES: We aimed to determine the role of beta-catenin in alveolar epithelium during bleomycin-induced lung fibrosis. | Bleomycin | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 3 | MEASUREMENTS AND MAIN RESULTS: Increased beta-catenin expression was noted in lung parenchyma after bleomycin. | Bleomycin | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 4 | Mice with selective deletion of beta-catenin in AECs had greater AEC death at 1 week after bleomycin, followed by increased numbers of fibroblasts and enhanced lung fibrosis as determined by semiquantitative histological scoring and total collagen content. | Bleomycin | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 5 | In vitro, beta-catenin-deficient AECs showed increased bleomycin-induced cytotoxicity as well as reduced proliferation and impaired wound closure. | Bleomycin | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 6 | Consistent with these findings, mice with AEC beta-catenin deficiency showed delayed recovery after bleomycin. | Bleomycin | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 7 | CONCLUSIONS: beta-Catenin in the alveolar epithelium protects against bleomycin-induced fibrosis. | Bleomycin | catenin (cadherin associated protein), beta 1 | Mus musculus |