Pub. Date : 2012
PMID : 23300844
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We show here that low-dose 5-aza treatment results in DNA damage and induction of p53 in NT2/D1 cells. | Azacitidine | tumor protein p53 | Homo sapiens |
2 | Low-dose 5-aza induces a p53 transcriptional signature distinct from that induced with cisplatin in NT2/D1 cells and also uniquely downregulates genes associated with pluripotency including NANOG, SOX2, GDF3 and Myc target genes. | Azacitidine | tumor protein p53 | Homo sapiens |
3 | Changes in the p53 and pluripotency signatures with 5-aza were to a large extent dependent on high levels of DNMT3B. | Azacitidine | tumor protein p53 | Homo sapiens |
4 | In contrast to the majority of p53 target genes upregulated by 5-aza that did not show DNA hypomethylation, several other genes induced with 5-aza had corresponding decreases in promoter methylation. | Azacitidine | tumor protein p53 | Homo sapiens |
5 | Our studies suggest that the hypersensitivity of NT2/D1 cells to low-dose 5-aza is multifactorial and involves the combined activation of p53 targets, repression of pluripotency genes, and activation of genes repressed by DNA methylation. | Azacitidine | tumor protein p53 | Homo sapiens |