Pub. Date : 2012
PMID : 23300837
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All-trans-retinoic acid modulates ICAM-1 N-glycan composition by influencing GnT-III levels and inhibits cell adhesion and trans-endothelial migration. | n-glycan | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | Homo sapiens |
| 2 | In the present study, we show that all-trans-retinoic acid (ATRA) modulates the N-glycan composition of intercellular adhesion molecule-1 (ICAM-1) by manipulating the expression of two N-acetylglucosaminyltransferases, GnT-III and GnT-V, via the ERK signaling pathway. | n-glycan | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | Homo sapiens |
| 3 | These data indicate that the alteration of ICAM-1 N-glycan composition by ATRA-induced GnT-III activities hindered cell adhesion and cell migration functions simultaneously, pinpointing a unique regulatory role of specific glycosyltransferases in the biological behaviors of tumor cells and a novel function of ATRA in the modulation of ICAM-1 N-glycan composition. | n-glycan | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | Homo sapiens |
| 4 | These data indicate that the alteration of ICAM-1 N-glycan composition by ATRA-induced GnT-III activities hindered cell adhesion and cell migration functions simultaneously, pinpointing a unique regulatory role of specific glycosyltransferases in the biological behaviors of tumor cells and a novel function of ATRA in the modulation of ICAM-1 N-glycan composition. | n-glycan | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | Homo sapiens |