Title : Fucoxanthin enhances cisplatin-induced cytotoxicity via NFκB-mediated pathway and downregulates DNA repair gene expression in human hepatoma HepG2 cells.

Pub. Date : 2013 Jan 8

PMID : 23299493






2 Functional Relationships(s)
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1 Cisplatin alone induced mRNA expression of excision repair cross complementation 1 (ERCC1) and thymidine phosphorylase (TP) through phosphorylation of ERK, p38 and PI3K/AKT pathways. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
2 However, fucoxanthin pretreatment significantly attenuated cisplatin-induced ERCC1 and TP mRNA expression, leading to improvement of chemotherapeutic efficacy of cisplatin. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens