Title : ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor.

Pub. Date : 2013 Jul

PMID : 23292912






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Lapatinib treatment caused a 50% inhibition in tumor growth, an effect correlated with a blockade of both ErbB1 and ErbB2 phosphorylation levels, and of downstream signaling pathways (Akt, ERKs and Stat3). Lapatinib signal transducer and activator of transcription 3 Homo sapiens