Title : (-)-Epigallocatechin-3-gallate inhibits human papillomavirus (HPV)-16 oncoprotein-induced angiogenesis in non-small cell lung cancer cells by targeting HIF-1α.

Pub. Date : 2013 Mar

PMID : 23292117






3 Functional Relationships(s)
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1 Additionally, 50 and 100 mumol/L of EGCG significantly reduced the secretion of VEGF and IL-8 proteins induced by HPV-16 E7 oncoprotein in NSCLC A549 cells. epigallocatechin gallate vascular endothelial growth factor A Mus musculus
2 Furthermore, EGCG inhibited HPV-16 oncoprotein-induced HIF-1alpha and HIF-1alpha-dependent VEGF and CD31 expression in A549 xenografted tumors. epigallocatechin gallate vascular endothelial growth factor A Mus musculus
3 CONCLUSIONS: EGCG inhibited HPV-16 oncoprotein-induced angiogenesis conferred by NSCLC through the inhibition of HIF-1alpha protein expression and HIF-1alpha-dependent expression of VEGF, IL-8, and CD31 as well as activation of Akt, suggesting that HIF-1alpha may be a potential target of EGCG against HPV-related NSCLC angiogenesis. epigallocatechin gallate vascular endothelial growth factor A Mus musculus