Pub. Date : 2013 Feb
PMID : 23287783
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. | Fingolimod Hydrochloride | plasminogen activator, tissue | Mus musculus |
| 2 | Combination of fingolimod and tPA improves the neurological outcome of the thrombolytic therapy and reduces the risk of hemorrhagic transformation associated with delayed administration of tPA. | Fingolimod Hydrochloride | plasminogen activator, tissue | Mus musculus |
| 3 | CONCLUSIONS: This study confirms the protective efficacy of fingolimod as a treatment against ischemic stroke in another rodent model of stroke (thromboembolic occlusion), and suggests that fingolimod could potentially be used in combination with tPA to reduce the risk of brain hemorrhage. | Fingolimod Hydrochloride | plasminogen activator, tissue | Mus musculus |