Title : Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding.

Pub. Date : 2012

PMID : 23285128






4 Functional Relationships(s)
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1 Mitochondrial DNA content and the expression of genes encoding multiple steps in mitochondrial fatty acid oxidation and oxidative phosphorylation pathways were significantly diminished in LS-PGC-1beta(-/-) mice. Fatty Acids peroxisome proliferative activated receptor, gamma, coactivator 1 beta Mus musculus
2 These results suggest that PGC-1beta plays dual roles in regulating hepatic fatty acid metabolism by controlling the expression of programs of genes involved in both fatty acid oxidation and de novo fatty acid synthesis. Fatty Acids peroxisome proliferative activated receptor, gamma, coactivator 1 beta Mus musculus
3 These results suggest that PGC-1beta plays dual roles in regulating hepatic fatty acid metabolism by controlling the expression of programs of genes involved in both fatty acid oxidation and de novo fatty acid synthesis. Fatty Acids peroxisome proliferative activated receptor, gamma, coactivator 1 beta Mus musculus
4 These results suggest that PGC-1beta plays dual roles in regulating hepatic fatty acid metabolism by controlling the expression of programs of genes involved in both fatty acid oxidation and de novo fatty acid synthesis. Fatty Acids peroxisome proliferative activated receptor, gamma, coactivator 1 beta Mus musculus